Clinical Evidence Spotlight

New Release

This article, published in Pain Medicine News, highlights real-world evidence demonstrating the effectiveness, safety, and durability of the Nalu Therapy System for chronic neuropathic pain. It also includes a compelling case study of a patient who trialed multiple neuromodulation devices before ultimately finding meaningful, lasting relief with Nalu.

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Long-Term Pain Relief Delivered by Micro-Implantable Pulse Generator: Findings from a Large-Scale, Real-World Data Peripheral Nerve Stimulation Patient Registry

John Hatheway, et al.

Published: 2025

Clinical Insights & Resources

Clinical Evidence Spotlight

New Release

Long-Term Pain Relief Delivered by Micro-Implantable Pulse Generator: Findings from a Large-Scale, Real-World Data Peripheral Nerve Stimulation Patient Registry

Long-Term Clinical Outcomes (24 Months) of Peripheral Nerve Stimulation in the Treatment of Chronic Pain – COMFORT RCT

A Confirmatory RCT Evaluating a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain 3- and 6-Month Results from the COMFORT 2 Study

Real-World Healthcare Utilization and Costs of Peripheral Nerve Stimulation with a micro-IPG System

Safety and Effectiveness of Intraoperative Neuromonitoring in Peripheral Nerve Stimulation: A Single-Center Real-World Data Analysis and Review

Articles

The Nalu micro-IPG: Advancing Neurostimulation for the Management of Chronic Neuropathic Pain

Peer Reviewed Publications

Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain: 12-Month Results from the COMFORT-Randomized Controlled Trial

Long-Term Pain Relief Delivered by Micro-Implantable Pulse Generator: Findings from a Large-Scale, Real-World Data Peripheral Nerve Stimulation Patient Registry

Modeling the Impact of the Variation in Peripheral Nerve Anatomy on Stimulation

Long-Term Clinical Outcomes (24 Months) of Peripheral Nerve Stimulation in the Treatment of Chronic Pain – COMFORT RCT

Design of a Multicenter, Randomized Controlled Trial for the Treatment of Peripheral Neuropathic Pain (COMFORT Study) with a Micro-Implantable Pulse Generator

Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain: 3-Month and 6-Month Results from the COMFORT-Randomised Controlled Trial

A Confirmatory RCT Evaluating a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain 3- and 6-Month Results from the COMFORT 2 Study

Real-World Healthcare Utilization and Costs of Peripheral Nerve Stimulation with a micro-IPG System

Safety and Effectiveness of Intraoperative Neuromonitoring in Peripheral Nerve Stimulation: A Single-Center Real-World Data Analysis and Review

Application of the Novel Nalu Neurostimulation System for Peripheral Nerve Stimulation

Posters

Nalu PNS Provides Significant Relief for Refractory Occipital Neuralgia and Cervical Facetogenic Pain

Superior Efficacy of Micro-Implantable Pulse Generator for Chronic Pain Management: COMFORT RCT One-Year Interim Results

Functional Outcomes from the COMFORT 2 RCT for Peripheral Nerve Stimulation: Early Results

Pain Outcomes from the COMFORT 2 RCT for Peripheral Nerve Stimulation-Early Results

Advanced Peripheral Nerve Stimulator Delivers Consistent Pain Relief Across Various Neuropathic Etiologies: COMFORT RCT Findings

Real World Data Shows Long-Term Pain Relief with Peripheral Nerve Stimulation Delivered from micro-IPG

The Nalu micro-IPG:
Advancing Neurostimulation for the Management of Chronic Neuropathic Pain